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H 2 O 2 signaling leads to the release of Nrf2 from complexes with Kelch-like ECH-associated protein 1 (Keap1) and ubiquitin ligase Cullin 3 and into the nucleus, where it binds to antioxidant response elements (ARE) and activates the expression of its target gene GPX8, which in turn regulates the expression of ER calcium by regulating SERCA (Granatiero et al., 2019)

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Name: CJC-1295 no DAC (Modified GRF 1-29) Purity: ~99% HPLC Vial Contents: Lyophilized Powder CAS Number: 863288-34-0 PubChem CID: 56841935 Molecular Weight: 3367.954 g/mol Molecular Formula: C152H252N44O42